Prof. David Margulies is the recipient of a MSMLG Czarnik Emerging Investigator Award. In their Communication on page 12477 ff., D. Margulies et al. Supra-molecular structures, based on synthetic molecules, DNA fragments, metal-complexes as well as light-harvesting groups, are applied in developing unconventional biosensors, protein mimetics, and molecular-based devices. E-mail address: david.margulies@weizmann.ac.il. b Department of Structural Biology, Weizmann Institute of Science, 76100 Rehovot, Israel Email: david.margulies@weizmann.ac.il. * Correspondence: david.margulies@weizmann.ac.il Abstract: Fluorescent sensing of biomolecules has served as a revolutionary tool for studying and better understanding various biological systems. Zohar Pode 1 , Ronny Peri-Naor 1 , Joseph M Georgeson 2 , Tal Ilani 2 , Vladimir Kiss 3 , Tamar Unger 4 , Barak Markus 5 , Haim M Barr 5 , Leila Motiei 1 , David Margulies 1 Affiliations 1 Department of Organic Chemistry, Weizmann Institute of Science, Rehovot 7610001, Israel. David Margulies A method for generating targeted, pattern-generating, protein surface sensors via the self-assembly of modified oligodeox-ynucleotides (ODNs) is described. Tel: +972 … By using this sensor to identify glycosylation states of a therapeutic protein, we … Prof. David Margulies has been awarded the NCK Prize for a Young Outstanding Medicinal Chemist of the Israel Chemical Society, Made of a single molecule, the tiny artificial sensor might be able to “smell out” disease within living cells. David Margulies archive | Weizmann Wonder Wander - News, Features and Discoveries from the Weizmann Institute of Science. D.M. Can a game with “quantum” rules beat the odds. Office: +972-8-934-2668 Lab: +972-8-934-xx Fax: +972-8-934-4142 David.Margulies@weizmann.ac.il. This approach involves two steps. is the incumbent of the Judith and Martin Freedman Career Development Chair. All rights reserved, Weizmann International Magazine of Science and People, Added particles in the atmosphere could be affecting rainfall patterns, Prof. Yoram Groner is a pioneer in Down syndrome research. Department of Organic Chemistry Weizmann Institute of Science Rehovot 76100, Israel. Molecule Holds the Key. Cooperative information protection is applied at the molecular scale by splitting a fluorescent DNA‐based key generator into four shares. Dr. David Margulies. 04.07.2016. 2 Department of Structural Biology , Weizmann Institute of Science , 76100 Rehovot , Israel. By creating molecular code generators that are selfâ assembled from several molecular components, we established a means for distributing distinct codeâ activating elements among several participants. david.margulies@weizmann.ac.il. Press. The research in our group is concerned with diverse aspects of bioorganic chemistry with emphasis on designing synthetic receptors that interact with proteins and sense or regulate their function. 2009- 2017, Department of Organic Chemistry. ... Department of Organic Chemistry The Weizmann Institute of Science, Rehovot, 76100 (Israel) Fax: (+972) 89342917. David Margulies. 1 Department of Organic Chemistry , Weizmann Institute of Science , 76100 Rehovot , Israel . Department of Organic Chemistry The Weizmann Institute of Science, Rehovot, 76100 (Israel) Fax: (+972) 89342917. Interaction Meeting on Materials, Chemistry, and Biology ... David Marguiles-Molecules that Generate ‘Fingerprints’: A New Class of Fluorescent Probes for … Search . Weizmann Wonder Wander Science news and culture. 3 Department of Chemical Research Support , Weizmann Institute of Science , 76100 Rehovot , Israel. david.margulies@weizmann.ac.il; Department of Organic Chemistry, Weizmann Institute of Science, 76100, Rehovot (Israel) Department of Organic Chemistry, Weizmann Institute of Science, 76100, Rehovot (Israel)Search for more papers by this author david.margulies@weizmann.ac.il; Department of Organic Chemistry, Weizmann Institute of Science, 76100, Rehovot (Israel) Department of Organic Chemistry, Weizmann Institute of Science, 76100, Rehovot (Israel)Search for more papers by this author * Corresponding authors a Department of Organic Chemistry, Weizmann Institute of Science, Rehovot 7610001, Israel E-mail: leila.motiei@weizmann.ac.il, david.margulies@weizmann.ac.il b Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot 7610001, Israel Associate Professor, Weizmann Institute of Science â Israel . Corresponding Author. David Margulies Optical cross-reactive sensor arrays (the so-called chemical “noses/tongues”) have recently been demonstrated as a powerful tool for high-throughput protein detecting and analysis. Prof. David Margulies is the recipient of a MSMLG Czarnik Emerging Investigator Award. Press. He. Department of Organic Chemistry, Weizmann Institute of Science, 76100, Rehovot (Israel) www.weizmann.ac.il/Organic_Chemistry/Margulies Weizmann Institute of Science researchers have now designed a method that combines secret writing with Enigma-like encryption, all in a single molecule. Abstract Invited for the cover of this issue is the group of David Margulies at the Weizmann Institute of Science (Israel). Search for more papers by this author Invited for the cover of this issue is the group of David Margulies at the Weizmann Institute of Science (Israel). David Margulies (david.margulies@weizmann.ac.il) Ulyana Shimanovich(ulyana.shimanovich@weizmann.ac.il) Official TWIM-2019 email: twim2019@gmail.com Program Schedule Talk Abstracts Posters . Abstract A method for decorating bacteria with synthetic receptors while they are attached to a solid support is described. Just add cola, Brain Research Gets a Boost from Mosquitos, A Senior Delegation from the Weizmann Institute of Science Visits MBZUAI Campus in Abu Dhabi, Weizmann Institute of Science. david.margulies@weizmann.ac.il; Department of Organic Chemistry, Weizmann Institute of Science, Rehovot, 7610001 Israel. Therefore, it has become increasingly important to identify fluorescent building blocks that can be easily converted into sensing probes, which can detect Our Research. Dr. David Margulies of the Institute’s Organic Chemistry Department, who headed the team, says that, in addition to the original method of encryption, the molecules he and his team have developed could also be used to “spy” on living cells. A methodology for creating fluorescent molecular sensors that respond to changes that occur on the surfaces of specific proteins is presented. This research was supported by the Peter and Patricia Gruber Foundation and by the Helen and Martin Kimmel Center for Molecular Design. atar.gilat@weizmann.ac.il. Ph.D studies at the Weizmann Institute of Science under supervision of Prof. Milko E. van der Boom studying the exponential formation of … David MARGULIES | Cited by 1,623 | of Weizmann Institute of Science, Reẖovot (weizmann) | Read 41 publications | Contact David MARGULIES Home Page; Area of Research ... Prof. David Margulies is the recipient of a MSMLG Czarnik Emerging Investigator Award. Linor Unger-Angel, a Bhimsen Rout, a Tal Ilani, b Miriam Eisenstein, c Leila Motiei, a and David Margulies a Linor Unger-Angel a Department of Organic Chemistry , Weizmann Institute of Science , 76100 Rehovot , Israel . David (Didi) Margulies and his group at the Weizmann Institute of Science are demonstrating nano-sized artificial noses that work something like real noses − that is, they can sense a number of different molecules in the environment and combine this information into a “scent.” What’s more, these molecular noses can “smell” inside a living cell. The image highlights the analogy between fluorescent molecular sensors and a miniaturized camera that can capture changes that occur at the nanoscale and shed light on the structural state of proteins. PI: Dr. Rina Rosenzweig, Prof. Emmanuel Doram Levy, Prof. Emmanuel Doram Levy, Prof. Emmanuel Doram Levy. Nanoscience, Organic Chemistry, … The lab employs a multidisciplinary approach that combines organic synthesis, protein mimicry, self-assembly, and fluorescent molecular sensor design in order to address fundamental challenges at the interface of chemistry and biology. show that four users must combine their shares and assemble the molecular security device to gain access. The simplicity by which these systems can be created enabled the development of a sensor that can straightforwardly discriminate between distinct glycoform populations. Search for more papers by this author. He. A method for generating targeted, pattern-generating, protein surface sensors via the self-assembly of modified oligodeoxynucleotides (ODNs) is described. (4)Department of Organic Chemistry, Weizmann Institute of Science, 76100, Rehovot (Israel). Home Page; Area of Research; Math & Computer Science; People; Space & Physics; Chemistry; Life Sciences ... Weizmann Institute of Science 234 Herzl Street, Rehovot 7610001 Israel . show how a series of nonspecific, fluorescent receptors can be “arrayed” on a single molecular platform. Linda S. Powers Prof. Dr. National Center for the Design of … E-mail: david.margulies@weizmann.ac.il. The research in our group is concerned with diverse aspects of bioorganic chemistry with emphasis on designing synthetic receptors that interact with proteins and sense or regulate their function. In their Communication on page 184 ff., D. Margulies et al. Email: news@weizmann.ac.il. X Menu. By responding to diverse chemical signals, the device generates unique … Research … We show that the binding of DNA-based artificial receptors to E. coli expressing His-tagged outer membrane protein C (His-OmpC) induces a Förster resonance energy transfer (FRET) between the dyes, which results in the generation of a unique fluorescence fingerprint. Invisible ink meets secure encryption in a single molecule. Search . 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